Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A

Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), the principal methyl donor in many biological processes. MAT2A is up-regulated in many cancers, including liver cancer and colorectal cancer (CRC) and is a potentially important drug tar...

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Dettagli Bibliografici
Autori principali: Zhang, Wen, Sviripa, Vitaliy, Chen, Xi, Shi, Jiandang, Yu, Tianxin, Hamza, Adel, Ward, Nicholas D., Kril, Liliia M., Kooi, Craig W. Vander, Zhan, Chang-Guo, Evers, B. Mark, Watt, David S., Liu, Chunming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631441/
https://ncbi.nlm.nih.gov/pubmed/23363077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3005353
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