Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface

We redesigned residues on the surface of MICA, a protein that binds the homodimeric immunoreceptor NKG2D, to increase binding affinity with a series of rational, incremental changes. A fixed-backbone RosettaDesign protocol scored a set of initial mutations, which we tested by surface plasmon resonan...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Henager, Samuel H, Hale, Melissa A, Maurice, Nicholas J, Dunnington, Erin C, Swanson, Carter J, Peterson, Megan J, Ban, Joseph J, Culpepper, David J, Davies, Luke D, Sanders, Lisa K, McFarland, Benjamin J
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
For the Record
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631368/
https://ncbi.nlm.nih.gov/pubmed/22761154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2115
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados