Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface

We redesigned residues on the surface of MICA, a protein that binds the homodimeric immunoreceptor NKG2D, to increase binding affinity with a series of rational, incremental changes. A fixed-backbone RosettaDesign protocol scored a set of initial mutations, which we tested by surface plasmon resonan...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Henager, Samuel H, Hale, Melissa A, Maurice, Nicholas J, Dunnington, Erin C, Swanson, Carter J, Peterson, Megan J, Ban, Joseph J, Culpepper, David J, Davies, Luke D, Sanders, Lisa K, McFarland, Benjamin J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wiley Subscription Services, Inc., A Wiley Company 2012
Gaiak:
For the Record
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631368/
https://ncbi.nlm.nih.gov/pubmed/22761154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2115
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak