Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners

Accumulating epidemiological evidence shows that obesity is associated with an increased risk of several types of adult cancers, including endometrial cancer. Chronic hyperinsulinemia, a typical hallmark of diabetes, is one of the leading factors responsible for the obesity-cancer connection. Numero...

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Bibliographic Details
Main Authors: Sarfstein, Rive, Friedman, Yael, Attias-Geva, Zohar, Fishman, Ami, Bruchim, Ilan, Werner, Haim
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631250/
https://ncbi.nlm.nih.gov/pubmed/23620761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061537
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