IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation

Plasmacytoid dendritic cells (pDCs) play a crucial role during innate immunity by secreting bulk amounts of type I interferons (IFNs) in response to Toll-like receptor (TLR)–mediated pathogen recognition. In addition, pDCs can also contribute to adaptive immunity by activation of antigen-specific T...

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Bibliographic Details
Main Authors: Karrich, Julien J., Jachimowski, Loes C. M., Nagasawa, Maho, Kamp, Angela, Balzarolo, Melania, Wolkers, Monika C., Uittenbogaart, Christel H., Marieke van Ham, S., Blom, Bianca
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630825/
https://ncbi.nlm.nih.gov/pubmed/23407551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-452995
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