Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression

The terminal differentiation of B cells into antibody-secreting plasma cells is tightly regulated by a complex network of transcription factors. Here we evaluated the role of the Ets factor Spi-B during terminal differentiation of human B cells. All mature tonsil and peripheral blood B-cell subsets...

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Main Authors: Schmidlin, Heike, Diehl, Sean A., Nagasawa, Maho, Scheeren, Ferenc A., Schotte, Remko, Uittenbogaart, Christel H., Spits, Hergen, Blom, Bianca
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518887/
https://ncbi.nlm.nih.gov/pubmed/18552212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-136440
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