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A mammalian pre-mRNA 5′-end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing
We recently reported that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5′-end capped mRNAs. Here we report that their mammalian homolog, Dom3Z, possesses pyrophosphohydrolase, decapping and 5′-3′ exoribonuclease activities, and...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630477/ https://ncbi.nlm.nih.gov/pubmed/23523372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.017 |
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