PKCα activation down-regulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo

We previously demonstrated that treatment of human androgen-responsive prostate cancer cell lines LNCaP and CWR22-Rv1 with 12-O-tetradecanoylphorbol 13-acetate (TPA), a known protein kinase C (PKC) activator, decreases ATM protein levels, thus de-repressing the enzyme ceramide synthase (CS) and prom...

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Detalhes bibliográficos
Main Authors: Truman, Jean-Philip, Rotenberg, Susan A., Kang, Ji-Hye, Lerman, Gabriel, Fuks, Zvi, Kolesnick, Richard, Marquez, Victor E., Haimovitz-Friedman, Adriana
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2009
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630174/
https://ncbi.nlm.nih.gov/pubmed/19029835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.8.1.7119
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