IgG Subclass and Heavy Chain Domains Contribute to Binding and Protection by mAbs to the Poly γ-D-glutamic Acid Capsular Antigen of Bacillus anthracis

Bacterial capsules are common targets for antibody-mediated immunity. The capsule of Bacillus anthracis is unusual among capsules because it is composed of a polymer of poly-γ-d-glutamic acid (γdPGA). We previously generated murine IgG3 monoclonal antibodies (mAbs) to γdPGA that were protective in a...

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Main Authors: Hovenden, Maria, Hubbard, Mark A., AuCoin, David P., Thorkildson, Peter, Reed, Dana E., Welch, William H., Lyons, C. Rick, Lovchik, Julie A., Kozel, Thomas R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630167/
https://ncbi.nlm.nih.gov/pubmed/23637599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003306
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