A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC(50)≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular...

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Main Authors: Vigant, Frederic, Lee, Jihye, Hollmann, Axel, Tanner, Lukas B., Akyol Ataman, Zeynep, Yun, Tatyana, Shui, Guanghou, Aguilar, Hector C., Zhang, Dong, Meriwether, David, Roman-Sosa, Gleyder, Robinson, Lindsey R., Juelich, Terry L., Buczkowski, Hubert, Chou, Sunwen, Castanho, Miguel A. R. B., Wolf, Mike C., Smith, Jennifer K., Banyard, Ashley, Kielian, Margaret, Reddy, Srinivasa, Wenk, Markus R., Selke, Matthias, Santos, Nuno C., Freiberg, Alexander N., Jung, Michael E., Lee, Benhur
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630091/
https://ncbi.nlm.nih.gov/pubmed/23637597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003297
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