A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC(50)≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular...

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Autors principals: Vigant, Frederic, Lee, Jihye, Hollmann, Axel, Tanner, Lukas B., Akyol Ataman, Zeynep, Yun, Tatyana, Shui, Guanghou, Aguilar, Hector C., Zhang, Dong, Meriwether, David, Roman-Sosa, Gleyder, Robinson, Lindsey R., Juelich, Terry L., Buczkowski, Hubert, Chou, Sunwen, Castanho, Miguel A. R. B., Wolf, Mike C., Smith, Jennifer K., Banyard, Ashley, Kielian, Margaret, Reddy, Srinivasa, Wenk, Markus R., Selke, Matthias, Santos, Nuno C., Freiberg, Alexander N., Jung, Michael E., Lee, Benhur
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630091/
https://ncbi.nlm.nih.gov/pubmed/23637597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003297
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