A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC(50)≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular...

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Bibliografische gegevens
Hoofdauteurs: Vigant, Frederic, Lee, Jihye, Hollmann, Axel, Tanner, Lukas B., Akyol Ataman, Zeynep, Yun, Tatyana, Shui, Guanghou, Aguilar, Hector C., Zhang, Dong, Meriwether, David, Roman-Sosa, Gleyder, Robinson, Lindsey R., Juelich, Terry L., Buczkowski, Hubert, Chou, Sunwen, Castanho, Miguel A. R. B., Wolf, Mike C., Smith, Jennifer K., Banyard, Ashley, Kielian, Margaret, Reddy, Srinivasa, Wenk, Markus R., Selke, Matthias, Santos, Nuno C., Freiberg, Alexander N., Jung, Michael E., Lee, Benhur
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630091/
https://ncbi.nlm.nih.gov/pubmed/23637597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003297
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