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A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC(50)≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630091/ https://ncbi.nlm.nih.gov/pubmed/23637597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003297 |
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