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TGF-β type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner

TGF-β superfamily members signal through a heteromeric receptor complex to regulate craniofacial development. TGF-β type II receptor appears to bind only TGF-β, whereas TGF-β type I receptor (ALK5) also binds to ligands in addition to TGF-β. Our previous work has shown that conditional inactivation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Hu, Oka, Kyoko, Bringas, Pablo, Kaartinen, Vesa, Chai, Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629921/
https://ncbi.nlm.nih.gov/pubmed/18572160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.03.045
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