The CRISPR System—Keeping Zebrafish Gene Targeting Fresh

We are entering a new era in our ability to modify and edit the genomes of model organisms. Zinc finger nucleases (ZFNs) opened the door to the first custom nuclease-targeted genome engineering in the late 1990s. However, ZFNs remained out of reach for most research labs because of the difficulty of...

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Bibliografiske detaljer
Main Authors: Blackburn, Patrick R., Campbell, Jarryd M., Clark, Karl J., Ekker, Stephen C.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2013
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629780/
https://ncbi.nlm.nih.gov/pubmed/23536990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/zeb.2013.9999
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