Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity

[Image: see text] The synthesis, molecular modeling, and pharmacological analysis of phenoxyalkylamino-4-phenylnicotinates (2–7), phenoxyalkoxybenzylidenemalononitriles (12, 13), pyridonepezils (14–18), and quinolinodonepezils (19–21) are described. Pyridonepezils 15–18 were found to be selective an...

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Autores principales: Silva, Daniel, Chioua, Mourad, Samadi, Abdelouahid, Agostinho, Paula, Garção, Pedro, Lajarín-Cuesta, Rocío, de los Ríos, Cristobal, Iriepa, Isabel, Moraleda, Ignacio, Gonzalez-Lafuente, Laura, Mendes, Eduarda, Pérez, Concepción, Rodríguez-Franco, María Isabel, Marco-Contelles, José, Carmo Carreiras, M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2013
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629749/
https://ncbi.nlm.nih.gov/pubmed/23379636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300178k
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