A novel class of early replicating fragile sites that contribute to genome instability in B cell lymphomas

DNA double strand breaks (DSBs) in B lymphocytes arise stochastically during replication or as a result of targeted DNA damage by activation induced cytidine deaminase (AID). Here we identify recurrent, early replicating and AID independent DNA lesions, termed early replication fragile sites (ERFS),...

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Bibliographic Details
Main Authors: Barlow, Jacqueline, Faryabi, Robert B., Callen, Elsa, Wong, Nancy, Malhowski, Amy, Chen, Hua Tang, Gutierez-Cruz, Gustavo, Sun, Hong-Wei, McKinnon, Peter, Wright, George, Casellas, Rafael, Robbiani, Davide F., Staudt, Louis, Fernandez-Capetillo, Oscar, Nussenzweig, André
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629730/
https://ncbi.nlm.nih.gov/pubmed/23352430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.01.006
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