Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis

Selk is an ER transmembrane protein important for calcium flux and macrophage activation, but its role in foam cell formation and atherosclerosis has not been evaluated. BMDMs from Selk(−/−) mice exhibited decreased uptake of modLDL and foam cell formation compared with WT controls, and the differen...

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Autores principales: Meiler, Svenja, Baumer, Yvonne, Huang, Zhi, Hoffmann, Fukun W., Fredericks, Gregory J., Rose, Aaron H., Norton, Robert L., Hoffmann, Peter R., Boisvert, William A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Leukocyte Biology 2013
Materias:
Inflammation, Extracellular Mediators, & Effector Molecules
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629442/
https://ncbi.nlm.nih.gov/pubmed/23444136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1212647
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