Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

Calcium (Ca(2+)) is a secondary messenger in cells and Ca(2+) flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells. Previous studies demonstrated that g...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fredericks, Gregory J., Hoffmann, FuKun W., Rose, Aaron H., Osterheld, Hanna J., Hess, Franz M., Mercier, Frederic, Hoffmann, Peter R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246275/
https://ncbi.nlm.nih.gov/pubmed/25368151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417176111
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