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Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8(+) T cell function in vitro

HIV infection is associated with elevated expression of IL-10 and PD-L1, contributing to impairment of T cell effector functions. In autoimmunity, tumor immunology, and some viral infections, Bregs modulate T cell function via IL-10 production. In this study, we tested the hypothesis that during HIV...

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Autors principals: Siewe, Basile, Stapleton, Jack T., Martinson, Jeffrey, Keshavarzian, Ali, Kazmi, Nazia, Demarais, Patricia M., French, Audrey L., Landay, Alan
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629440/
https://ncbi.nlm.nih.gov/pubmed/23434518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0912436
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