Thyrotropin-Releasing Hormone Receptor Type 1 (TRH-R1), not TRH-R2, Primarily Mediates Taltirelin Actions in the CNS of Mice

Thyrotropin-releasing hormone receptor type 2 (TRH-R2), not TRH-R1, has been proposed to mediate the CNS effects of TRH and its more effective analog taltirelin (TAL). Consistent with this idea, TAL exhibited higher binding affinity and signaling potency at mouse TRH-R2 than TRH-R1 in a model cell s...

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Bibliografske podrobnosti
Main Authors: Thirunarayanan, Nanthakumar, Nir, Eshel A, Raaka, Bruce M, Gershengorn, Marvin C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629383/
https://ncbi.nlm.nih.gov/pubmed/23303050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.256
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