Sirt1 activation by resveratrol is substrate sequence-selective

Sirtuins are protein deacetylases used as therapeutic targets. Pharmacological Sirt1 activation has been questioned since the in vitro activator resveratrol failed to stimulate deacetylation of several physiological substrates. We tested the influence of substrate sequence by analyzing resveratrol e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Lakshminarasimhan, Mahadevan, Rauh, David, Schutkowski, Mike, Steegborn, Clemens
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2013
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629287/
https://ncbi.nlm.nih.gov/pubmed/23524286
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