Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication.

NIH 3T3 cells infected with Moloney murine leukemia virus (MoMLV) express high levels of virus-specific RNA. To inhibit replication of the virus, we stably introduced chimeric tRNA genes encoding antisense templates into NIH 3T3 cells via a retroviral vector. Efficient expression of hybrid tRNA-MoML...

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Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Sullenger, B A, Lee, T C, Smith, C A, Ungers, G E, Gilboa, E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 1990
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Research Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362928/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2247070/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.12.6512
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