Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus

Newer therapies are needed for the treatment of status epilepticus (SE) refractory to benzodiazepines. Enhanced glutamatergic neurotransmission leads to SE, and AMPA receptors are modified during SE. Reducing glutamate release during SE is a potential approach to terminate SE. The neuropeptide somat...

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Main Authors: Kozhemyakin, Maxim, Rajasekaran, Karthik, Todorovic, Marko S., Kowalski, Samuel L., Balint, Corinne, Kapur, Jaideep
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628955/
https://ncbi.nlm.nih.gov/pubmed/23473742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.02.015
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