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Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus

Newer therapies are needed for the treatment of status epilepticus (SE) refractory to benzodiazepines. Enhanced glutamatergic neurotransmission leads to SE, and AMPA receptors are modified during SE. Reducing glutamate release during SE is a potential approach to terminate SE. The neuropeptide somat...

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Autors principals: Kozhemyakin, Maxim, Rajasekaran, Karthik, Todorovic, Marko S., Kowalski, Samuel L., Balint, Corinne, Kapur, Jaideep
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628955/
https://ncbi.nlm.nih.gov/pubmed/23473742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.02.015
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