Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

We describe the cloning and function of the human XRCC1 gene, which is the first mammalian gene isolated that affects cellular sensitivity to ionizing radiation. The CHO mutant EM9 has 10-fold-higher sensitivity to ethyl methanesulfonate, 1.8-fold-higher sensitivity to ionizing radiation, a reduced...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Thompson, L H, Brookman, K W, Jones, N J, Allen, S A, Carrano, A V
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362891/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2247054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.12.6160-6171.1990
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