Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via G(i) and Akt-Dependent Actin Cytoskeleton Remodeling

BACKGROUND: In a neonatal model of hypoxic pulmonary hypertension, a dramatic pulmonary artery adventitial thickening, accumulation of inflammatory cells in the adventitial compartment, and angiogenic expansion of the vasa vasorum microcirculatory network are observed. These pathophysiological respo...

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Main Authors: Siddaramappa Umapathy, Nagavedi, Kaczmarek, Elzbieta, Fatteh, Nooreen, Burns, Nana, Lucas, Rudolf, Stenmark, Kurt R., Verin, Alexander D., Gerasimovskaya, Evgenia V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628712/
https://ncbi.nlm.nih.gov/pubmed/23613714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059733
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