Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation

Myeloid ecotropic viral integration site 1 (Meis1) forms a heterodimer with Pbx1 that augments Hox-dependent gene expression and is associated with leukemogenesis and HSC self-renewal. Here we identified 2 independent actions of Meis1 in hematopoietic development: one regulating cellular proliferati...

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Autors principals: Cai, Mi, Langer, Ellen M., Gill, Jennifer G., Satpathy, Ansuman T., Albring, Jörn C., KC, Wumesh, Murphy, Theresa L., Murphy, Kenneth M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628121/
https://ncbi.nlm.nih.gov/pubmed/22665933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403139
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