HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α–induced excessive erythropoiesis

Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible factor (HIF). Accumulating evidence suggests that oxygen-sensitive prolyl hyd...

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Main Authors: Franke, Kristin, Kalucka, Joanna, Mamlouk, Soulafa, Singh, Rashim Pal, Muschter, Antje, Weidemann, Alexander, Iyengar, Vasuprada, Jahn, Steffen, Wieczorek, Kathrin, Geiger, Kathrin, Muders, Michael, Sykes, Alex M., Poitz, David M., Ripich, Tatsiana, Otto, Teresa, Bergmann, Sybille, Breier, Georg, Baretton, Gustavo, Fong, Guo-Hua, Greaves, David R., Bornstein, Stefan, Chavakis, Triantafyllos, Fandrey, Joachim, Gassmann, Max, Wielockx, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628111/
https://ncbi.nlm.nih.gov/pubmed/23264599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449181
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