Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

EZH2 plays an important role in stem cell renewal and maintenance by inducing gene silencing via its histone methyltransferase activity. Previously, we showed that EZH2 downregulation enhances neuron differentiation of human mesenchymal stem cells (hMSCs); however, the underlying mechanisms of EZH2-...

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Hlavní autoři: Yu, Yung-Luen, Chou, Ruey-Hwang, Shyu, Woei-Cherng, Hsieh, Shu-Ching, Wu, Chen-Shiou, Chiang, Shu-Ya, Chang, Wei-Jung, Chen, Jia-Ni, Tseng, Yen-Ju, Lin, Yu-Hsuan, Lee, Wei, Yeh, Su-Peng, Hsu, Jennifer L, Yang, Cheng-Chieh, Hung, Shih-Chieh, Hung, Mien-Chie
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628108/
https://ncbi.nlm.nih.gov/pubmed/23526793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201783
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