Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

EZH2 plays an important role in stem cell renewal and maintenance by inducing gene silencing via its histone methyltransferase activity. Previously, we showed that EZH2 downregulation enhances neuron differentiation of human mesenchymal stem cells (hMSCs); however, the underlying mechanisms of EZH2-...

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Bibliografske podrobnosti
Main Authors: Yu, Yung-Luen, Chou, Ruey-Hwang, Shyu, Woei-Cherng, Hsieh, Shu-Ching, Wu, Chen-Shiou, Chiang, Shu-Ya, Chang, Wei-Jung, Chen, Jia-Ni, Tseng, Yen-Ju, Lin, Yu-Hsuan, Lee, Wei, Yeh, Su-Peng, Hsu, Jennifer L, Yang, Cheng-Chieh, Hung, Shih-Chieh, Hung, Mien-Chie
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628108/
https://ncbi.nlm.nih.gov/pubmed/23526793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201783
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