STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

Myocarditis, often triggered by viral infection, may lead to heart auto-immunity and dilated cardiomyopathy. What determines the switch between disease resolution and progression is however incompletely understood. We show that pharmacological inhibition of STAT3, the main mediator of IL-6 signallin...

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Hlavní autoři: Camporeale, Annalisa, Marino, Francesca, Papageorgiou, Anna, Carai, Paolo, Fornero, Sara, Fletcher, Steven, Page, Brent D G, Gunning, Patrick, Forni, Marco, Chiarle, Roberto, Morello, Mara, Jensen, Ole, Levi, Renzo, Heymans, Stephane, Poli, Valeria
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628107/
https://ncbi.nlm.nih.gov/pubmed/23460527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201876
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