Modeling the Neuroprotective Role of Enhanced Astrocyte Mitochondrial Metabolism during Stroke

A mathematical model that integrates the dynamics of cell membrane potential, ion homeostasis, cell volume, mitochondrial ATP production, mitochondrial and endoplasmic reticulum Ca(2+) handling, IP(3) production, and GTP-binding protein-coupled receptor signaling was developed. Simulations with this...

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Detalhes bibliográficos
Main Authors: Diekman, Casey O., Fall, Christopher P., Lechleiter, James D., Terman, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Systems Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627876/
https://ncbi.nlm.nih.gov/pubmed/23601322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.02.025
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