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Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats
Targeted genome engineering requires nucleases that introduce a highly specific double-strand break in the genome that is either processed by homology-directed repair in the presence of a homologous repair template or by non-homologous end-joining (NHEJ) that usually results in insertions or deletio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627573/ https://ncbi.nlm.nih.gov/pubmed/23408850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt080 |
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