Comparative Analysis of Temporal and Dose-Dependent TCDD-Elicited Gene Expression in Human, Mouse, and Rat Primary Hepatocytes

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)–elicited time- and dose-dependent differential gene expression was compared in human, mouse, and rat primary hepatocytes. Comprehensive time course (10 nM TCDD or dimethyl sulfoxide vehicle control for 1, 2, 4, 8, 12, 24, and 48h) studies identified 495, 23...

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Autors principals: Forgacs, Agnes L., Dere, Edward, Angrish, Michelle M., Zacharewski, Timothy R.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627554/
https://ncbi.nlm.nih.gov/pubmed/23418086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft028
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