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When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva (FOP)

A heterozygous missense mutation in activin receptor IA/activin-like kinase-2 (ACVR1/ALK2), a bone morphogenetic protein (BMP) type I receptor, is responsible for fibrodysplasia ossificans progressiva (FOP), the most catastrophic disorder of skeletal metamorphosis in humans. The discovery of the FOP...

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Autores principales: Kaplan, Frederick S., Groppe, Jay, Shore, Eileen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627400/
https://ncbi.nlm.nih.gov/pubmed/23599718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddstr.2008.11.004
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