Histone Deacetylase Inhibitors Enhance the Apoptotic Activity of Insulin-Like Growth Factor Binding Protein-3 by Blocking PKC-Induced IGFBP-3 Degradation

Overexpression of insulin-like growth factor binding protein (IGFBP)-3 induces apoptosis of cancer cells. However, preexisting resistance to IGFBP-3 could limit its antitumor activities. This study characterizes the efficacy and mechanism of the combination of recombinant IGFBP-3 (rIGFBP-3) and HDAC...

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Autori principali: Oh, Seung Hyun, Whang, Young Mi, Min, Hye-Young, Han, Seung Ho, Kang, Ju-Hee, Song, Ki-Hoon, Glisson, Bonnie S., Kim, Yeul Hong, Lee, Ho-Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627058/
https://ncbi.nlm.nih.gov/pubmed/22362554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27509
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