Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells

OBJECTIVE: To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. METHODS: The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cell cycle and mitochondrial membrane pote...

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Detalhes bibliográficos
Main Authors: Xu, Jingyan, Zhou, Min, Ouyang, Jian, Wang, Jing, Zhang, Qiguo, Xu, Yong, Xu, Yueyi, Zhang, Qian, Xu, Xihui, Zeng, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626980/
https://ncbi.nlm.nih.gov/pubmed/23592899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.1000-9604.2013.02.06
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