IL-21 promotes the expansion of CD27(+)CD28(+) tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells

BACKGROUND: Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effector T cells requires extensive ex vivo expansion, often at the cost of T cell di...

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Detaylı Bibliyografya
Asıl Yazarlar: Santegoets, Saskia JAM, Turksma, Annelies W, Suhoski, Megan M, Stam, Anita GM, Albelda, Steve M, Hooijberg, Erik, Scheper, Rik J, van den Eertwegh, Alfons JM, Gerritsen, Winald R, Powell, Daniel J, June, Carl H, de Gruijl, Tanja D
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626797/
https://ncbi.nlm.nih.gov/pubmed/23402380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-37
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