IL-21 promotes the expansion of CD27(+)CD28(+) tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells

BACKGROUND: Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effector T cells requires extensive ex vivo expansion, often at the cost of T cell di...

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Hauptverfasser: Santegoets, Saskia JAM, Turksma, Annelies W, Suhoski, Megan M, Stam, Anita GM, Albelda, Steve M, Hooijberg, Erik, Scheper, Rik J, van den Eertwegh, Alfons JM, Gerritsen, Winald R, Powell, Daniel J, June, Carl H, de Gruijl, Tanja D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626797/
https://ncbi.nlm.nih.gov/pubmed/23402380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-37
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