IL-21 promotes the expansion of CD27(+)CD28(+) tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells

BACKGROUND: Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effector T cells requires extensive ex vivo expansion, often at the cost of T cell di...

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Bibliografiska uppgifter
Huvudupphovsmän: Santegoets, Saskia JAM, Turksma, Annelies W, Suhoski, Megan M, Stam, Anita GM, Albelda, Steve M, Hooijberg, Erik, Scheper, Rik J, van den Eertwegh, Alfons JM, Gerritsen, Winald R, Powell, Daniel J, June, Carl H, de Gruijl, Tanja D
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2013
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626797/
https://ncbi.nlm.nih.gov/pubmed/23402380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-37
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