Genetic variations of the A13/A14 repeat located within the EGFR 3′ untranslated region have no oncogenic effect in patients with colorectal cancer

BACKGROUND: The EGFR 3′ untranslated region (UTR) harbors a polyadenine repeat which is polymorphic (A13/A14) and undergoes somatic deletions in microsatellite instability (MSI) colorectal cancer (CRC). These mutations could be oncogenic in colorectal tissue since they were shown to result into incr...

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Detalhes bibliográficos
Main Authors: Sarafan-Vasseur, Nasrin, Sefrioui, David, Tougeron, David, Lamy, Aude, Blanchard, France, Le Pessot, Florence, Di Fiore, Frédéric, Michel, Pierre, Bézieau, Stéphane, Latouche, Jean-Baptiste, Frebourg, Thierry, Sesboüé, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626788/
https://ncbi.nlm.nih.gov/pubmed/23565769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-183
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