Acetylation of Human TCF4 (TCF7L2) Proteins Attenuates Inhibition by the HBP1 Repressor and Induces a Conformational Change in the TCF4::DNA Complex

The members of the TCF/LEF family of DNA-binding proteins are components of diverse gene regulatory networks. As nuclear effectors of Wnt/β-catenin signaling they act as assembly platforms for multimeric transcription complexes that either repress or activate gene expression. Previously, it was show...

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Bibliografiska uppgifter
Huvudupphovsmän: Elfert, Susanne, Weise, Andreas, Bruser, Katja, Biniossek, Martin L., Jägle, Sabine, Senghaas, Niklas, Hecht, Andreas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626699/
https://ncbi.nlm.nih.gov/pubmed/23613959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061867
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