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Calpain Inhibition Reduces Amplitude and Accelerates Decay of the Late Sodium Current in Ventricular Myocytes from Dogs with Chronic Heart Failure

Calpain is an intracellular Ca(2+) -activated protease that is involved in numerous Ca(2+) dependent regulation of protein function in many cell types. This paper tests a hypothesis that calpains are involved in Ca(2+) -dependent increase of the late sodium current (I(NaL)) in failing heart. Chronic...

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Main Authors: Undrovinas, Albertas, Maltsev, Victor A., Sabbah, Hani N.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626653/
https://ncbi.nlm.nih.gov/pubmed/23596505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054436
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