Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.

We determined the fidelity of avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases (RTs) during DNA synthesis in vitro using the M13mp2 lacZ alpha gene as a mutational target. Both RTs commit an error approximately once for every 30,000 nucleotides polymerized. DNA seq...

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Detalhes bibliográficos
Main Authors: Roberts, J D, Preston, B D, Johnston, L A, Soni, A, Loeb, L A, Kunkel, T A
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC362622/
https://ncbi.nlm.nih.gov/pubmed/2469002
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