Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.

We determined the fidelity of avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases (RTs) during DNA synthesis in vitro using the M13mp2 lacZ alpha gene as a mutational target. Both RTs commit an error approximately once for every 30,000 nucleotides polymerized. DNA seq...

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Détails bibliographiques
Auteurs principaux: Roberts, J D, Preston, B D, Johnston, L A, Soni, A, Loeb, L A, Kunkel, T A
Format: Artigo
Langue:Inglês
Publié: 1989
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC362622/
https://ncbi.nlm.nih.gov/pubmed/2469002
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