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GVHD impairs vaccine responses through decreased CD4(+) and CD8(+) T cell proliferation and increased perforin-mediated CD8(+) T cell apoptosis()
Tumor-targeted vaccines represent a strategy to enhance the graft-versus-leukemia effect following allogeneic blood or marrow transplantation (alloBMT). We have previously shown that GVHD can negatively impact quantitative responses to vaccines. Using a minor histocompatibility antigen (mHA)-mismatc...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3626171/ https://ncbi.nlm.nih.gov/pubmed/23275602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200391 |
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