GVHD impairs vaccine responses through decreased CD4(+) and CD8(+) T cell proliferation and increased perforin-mediated CD8(+) T cell apoptosis()

Tumor-targeted vaccines represent a strategy to enhance the graft-versus-leukemia effect following allogeneic blood or marrow transplantation (alloBMT). We have previously shown that GVHD can negatively impact quantitative responses to vaccines. Using a minor histocompatibility antigen (mHA)-mismatc...

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Hauptverfasser: Capitini, Christian M., Nasholm, Nicole M., Duncan, Brynn B., Guimond, Martin, Fry, Terry J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626171/
https://ncbi.nlm.nih.gov/pubmed/23275602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200391
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