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Acquisition of a novel eleven amino acid insertion directly N-terminal to a tetrabasic cleavage site confers intracellular cleavage of an H7N7 influenza virus hemagglutinin

A critical feature of highly pathogenic avian influenza viruses (H5N1 and H7N7) is the efficient intracellular cleavage of the hemagglutinin (HA) protein. H7N7 viruses also exist in equine species, and a unique feature of the equine H7N7 HA is the presence of an eleven amino acid insertion directly...

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Detalhes bibliográficos
Main Authors: Hamilton, Brian S., Sun, Xiangjie, Chung, Changik, Whittaker, Gary R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626165/
https://ncbi.nlm.nih.gov/pubmed/23051710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.09.004
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