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A chemical biology strategy to analyze rheostat-like protein kinase-dependent regulation
Protein kinases may function more like variable rheostats, rather than two-state switches. However, we lack approaches to properly analyze this aspect of kinase-dependent regulation. To address this we develop a strategy in which a kinase inhibitor is identified using genetics-based screens, kinase...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3626098/ https://ncbi.nlm.nih.gov/pubmed/23438755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.01.003 |
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