MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance

The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatid...

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Hauptverfasser: Zmajkovicova, Katarina, Jesenberger, Veronika, Catalanotti, Federica, Baumgartner, Christian, Reyes, Gloria, Baccarini, Manuela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625979/
https://ncbi.nlm.nih.gov/pubmed/23453810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.01.037
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