Muscle metaboreflex-induced coronary vasoconstriction limits ventricular contractility during dynamic exercise in heart failure

Muscle metaboreflex activation (MMA) during dynamic exercise increases cardiac work and myocardial O(2) demand via increases in heart rate, ventricular contractility, and afterload. This increase in cardiac work should lead to metabolic coronary vasodilation; however, no change in coronary vascular...

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Bibliographic Details
Main Authors: Coutsos, Matthew, Sala-Mercado, Javier A., Ichinose, Masashi, Li, ZhenHua, Dawe, Elizabeth J., O'Leary, Donal S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625893/
https://ncbi.nlm.nih.gov/pubmed/23355344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00879.2012
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