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RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells

We have utilized retinoic acid receptor γ (gamma) knockout (RARγ(−/−)) embryonic stem (ES) cells as a model system to analyze RARγ mediated transcriptional regulation of stem cell differentiation. Most of the transcripts regulated by all-trans retinoic acid (RA) in ES cells are dependent upon functi...

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Hlavní autoři: Kashyap, Vasundhra, Laursen, Kristian B., Brenet, Fabienne, Viale, Agnes J., Scandura, Joseph M., Gudas, Lorraine J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625813/
https://ncbi.nlm.nih.gov/pubmed/23264745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.119701
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