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Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ

Ethanol (EtOH) is a teratogen, but its teratogenic mechanisms are not fully understood. The alcohol form of vitamin A (retinol/ROL) can be oxidized to all-trans-retinoic acid (RA), which plays a critical role in stem cell differentiation and development. Using an embryonic stem cell (ESC) model to a...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Serio, Ryan N., Laursen, Kristian B., Urvalek, Alison M., Gross, Steven S., Gudas, Lorraine J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462535/
https://ncbi.nlm.nih.gov/pubmed/30737277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007153
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